A factory in Keilor Park was fully ablaze early on Monday morning.
Just before 1am, Fire Rescue Victoria (FRV) responded to the fire on Thomsons Road, where a 10 metre by 15 metre slab factory was alight.
Firefighters entered the burning building with hoselines and assisted by an aerial firefighting appliance began to extinguish the fire whilst also protecting adjoining fatories.
No persons were inside the factory at the time of the fire.
The fire was declared under control at 01.42am, 44 minutes after FRV arrived on scene.
The factory sustained significant damage in the fire.
The cause of the fire is yet to be determined but will be investigated.
Victoria Police and Ambulance Victoria attended in support of FRV operations.