Two lanes of the Keilor Park Drive exit from the Calder Freeway inbound are closed following a truck spillage.
Chicken carcasses have been spread across the road following truck spill.
Both right turning lanes are closed, with all drivers needing to turn left at the lights.
Drivers are being told to consider Fullerton Road or the Western Ring Road at Airport Drive.
VicRoads staff and police are on the scene.