Brimbank recorded its highest number of daily cases in the latest COVID-19 outbreak on Sunday.
Cases have steadily grown in the area over the last week, with 150 cases announced on Sunday as the state recorded its highest daily total to date.
Brimbank recorded more than 100 cases on five of the seven days last week.
A man in his 50s from Brimbank was among five people who died in the 24 hours to Sunday.
He was the second Brimbank resident to die from coronavirus in the last week.
Brimbank currently has the fourth highest number of active cases in the state, behind Hume, Whittlesea and Casey.
The neighbouring Melton municipality has also seen an increase in cases, with 154 on Sunday.
The 3023 postcode, which was earlier in the week announced as a target area due to lower vaccination rates, has the most active cases in Brimbank, with 427 active cases.
The 3037 postcode which was also on the vaccine target list, is also in the top 10 for active cases.
Despite the increase in cases in the area, only four Brimbank suburbs have exposure sites according to the Department of Health.
They are Braybrook, Derrimut, Sydenham and Tullamarine.
Meanwhile, the state government has announced that crowds will be allowed at the Melbourne Cup.
Up to 10,000 people will be able to attend the Melbourne Cup under a COVIDsafe plan. If the state is yet to hit the 80 per cent double vaccination rate, it will be limited to people who live within 25 kilometres.
The final two days of the Springs Carnival will also be open to crowds, if the vaccination threshold has been met.