The Green Gully Road entry ramp to the Calder Freeway will be closed this weekend.
The ramp will be closed from 6.30am on Saturday, March 17 and reopened at 5am, Monday, March 19.
VicRoads said the ramp was being closed to complete works.
Closures will also apply to Arundel Road, southbound between Milburn Road and Green Gully Road on Saturday and Sunday from 7am to 7pm.
The Tullamarine Freeway will also be closed between Melrose Drive and Melbourne Airport on Saturday.
Closures will apply to outbound (to the airport) traffic between 10pm-5am and inbound (to the city) traffic between 11pm-5am.
Detours will be in place.
For further information visit: www.vicroads.vic.gov.au.
